This article lists all of the various background character deaths that occur in the comic-book movie Deadpool 2.
- In the prologue montage narrated by Deadpool himself, Deadpool crashes a meeting between members of a sex-trafficking ring in Hong Kong. After crashing through a window and getting shot up, the merc with a mouth recovers thanks to his healing ability and slaughters the gangsters with a mixture of gunshots, decapitations, throat slices and impalements.
- In Sicily, Italy, Deadpool crashes a mafia funeral by bursting out of the coffin of the deceased and gunning down all of the mobsters in attendance.
- In Biloxi, Mississippi, Deadpool disguises himself (poorly) as a stripper in order to get close to a trio of criminals. After slashing one of them, he gets behind the second and grabs him, forcing him to shoot the third crook before slitting his throat.
- In Osaka, Japan, Deadpool confronts twelve Yakuza members in a bath house, all of whom are carrying swords. In the ensuing fight, most of the Yakuza are hacked to pieces, although three of them manage to run Deadpool through with their blades. Of course, this doesn't stop Deadpool and he quickly pulls their swords out of his torso and slashes the trio with them.
- In New York, Sergei Valishnikov is running through his drug factory while Deadpool is killing all of his goons. At least two goons are shot, another is slashed by Deadpool's katana, one is beaten with a sledgehammer and another is seen running around while on fire.
- Inside his panic room, Sergei watches one of his henchmen on a monitor begging to be let in. The camera is suddenly spattered with blood when Deadpool shoots the henchman in the head.
- Sergei and four goons break into Vanessa Carlysle's apartment looking to kill Deadpool. Deadpool kills the four goons using a selection of kitchen knives.
- After Russell Collins is restrained, he reveals to Deadpool that the staff at Essex House had been torturing him. Deadpool responds to this by shooting a nearby orderly.
- At the Ice Box, two guards are killed when Cable blasts through a wall.
- Cable throws an explosive device into a monitor station, killing three personnel.
- Cable beats a guard to death and shoots two others.
- Cable shoots another guard with his rifle as he pursues Russell.
- As X-Force begin their mission to save Russell, Domino lands in the middle of a busy road, causing several cars to crash. While it's possible that some of the crash victims may have survived, one crashes into a gas station which then explodes, undoubtedly killing the driver and anyone who was in the station. Due to her power of altering probability, Domino is completely unscathed.
- Cable launches a grenade at the DMC truck that Domino is now driving. However, sunlight reflects off of the spinning rear-view mirror and gets in Cable's eye, causing him to misfire. The grenade soars underneath the front truck in the convoy and blows up the truck behind it.
- Two prisoners aboard the DMC landtrain are possibly killed when Cable pushes their cages out onto the road.
- Domino fires a volley of bullets into the back of the landtrain, striking one of Cable's explosives and setting it off. The caboose is destroyed and the remaining cages fall into the road, most likely killing their occupants.
- Deadpool winds up on the windscreen of a trailing DMC truck. He punches through the windscreen and grabs at the driver who raises a gun. The driver shoots a hole through Deadpool's hand, but Deadpool forces the gun to point back at the driver's head and shoots him.
- It is unknown how many innocent bystanders were killed during the convoy scene.
- Cable explains his backstory to Deadpool, about how Firefist broke into his home and incinerated his wife and daughter.
- During the climactic battle at Essex House, Domino battles three orderlies inside the building. Due to her luck-altering powers, her opponents each die due to comical mishaps. One orderly trips and breaks his neck against a metal bedframe, another falls and stabs himself in the neck and the last one is trapped between several bedframes and then decapitated by a falling locker.
- Deadpool and Cable shoot all of the orderlies outside the house in comedic fashion.
- During the mid-credits scene, Deadpool uses Cable's repaired time-slider to go back in time. First, he goes back and stops Vanessa from being killed. Next, he goes back to X-Men Origins: Wolverine and kills that film's version of himself. He then goes back to 2006 and shoots Ryan Reynolds before he can star in Green Lantern. Finally, he travels back to 1889 and attempts to kill Adolf Hitler as a baby, but ultimately doesn't go through with it.