Jennifer Sisko (portrayed by Felicia M. Bell) was the first wife of Benjamin Sisko in Star Trek: Deep Space Nine. She is already deceased when the series begins, having perished aboard the USS Saratoga during Starfleet's doomed conflict against the Borg at Wolf 359. Jennifer was in her quarters with her son Jake when a Borg weapons discharge crippled the ship, causing heavy damage across all decks. A bulkhead in the Siskos' quarters collapsed and Jennifer was killed.
Throughout the pilot episode "Emissary", Benjamin is still struggling emotionally over Jennifer's death and the pain of her loss causes him to consider resigning from Starfleet. It is not until his first encounter with the aliens residing in the Bajoran Wormhole - one of which assumes Jennifer's form - that Benjamin finally comes to terms with Jennifer's loss and learns to move on.