Megatron is the maniacal leader of the Decepticons in most of the different Transformers continuities. A power-hungry tyrant and merciless warrior, Megatron's ultimate goal is to dominate his homeworld Cybertron, and from there conquer the universe. Standing between him and his ultimate conquest are the Autobots, led by the noble Optimus Prime.

Like Optimus Prime, Megatron has suffered multiple deaths across the various Transformers continuities, usually being killed in battle by his hated adversary.