In 2373, Ghemor visited Kira on Deep Space 9 in response to Kira's proposal that he become the leader of a Cardassian opposition to the Cardassian/Dominion alliance. When Ghemor was asked what he thought about the proposal Kira had sent him, he had to decline, despite Kira's enthusiasm and arguments that he would be the best person to lead the opposition, perhaps even being able to counter the Cardassian Union's propaganda. It was then that Ghemor revealed he was suffering from Yarim Fel Syndrome, a terminal disease. Doctor Julian Bashir, at Kira's request, confirmed the diagnosis of Yarim Fel Syndrome. The disease had already spread throughout his body and Bashir could predict exactly how much time Ghemor had left. Though he advised Ghemor that there were some treatments available to them, such as hexadrin therapy, the prognosis was not good.
With little time left, Ghemor chose to pass on his political and military secrets to Kira. During his final days, Gul Dukat and Weyoun paid Ghemor a visit, hoping to silence him. They claimed that Ghemor had been exonorated of his political crimes and offered to let him return to Cardassia, but Ghemor refused to have his name sullied by Dominion propaganda. Dukat even attempted to turn Kira against him by giving her Ghemor's military history. Kira had previously been told that Ghemor had played no part during the Occupation of Bajor, but his record proved otherwise. In the end, Kira chose to disregard Ghemor's past and she remained at his bedside as he succumbed to his illness.
After his death, Ghemor's body was buried on Bajor, right next to the grave of Kira's own father.